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Destroy All Humans! 2: Reprobed is played from a third-person perspective. It is an action-adventure game that involves both shooting and stealth elements. As players progress throughout the game, new weapons, new abilities, better stats, and access to new vehicles are unlocked. The game is set across five locations: Bay City, Albion, Takoshima, Tunguska, and the Solaris moon base (some of which are parodies of real-life locations such as San Francisco, London, and Tokyo). Several of these locations have been expanded in size from the original game, adding new areas to explore.
Multiplayer: The game's campaign is fully playable in both single-player and two-player local split-screen co-op.
